VUS Genetics Information

VUS Genetics is building the gene variant-level functional data platform for targeted treatment in oncology and for rare genetic diseases. Through our proprietary geneSlice functional genomics platform — exclusively licensed from SickKids Hospital, Toronto — we generate drug response data at the individual gene variant level, giving biopharma the evidence they need to match the right patients to the right drugs. We work in asset-focused partnerships with biotech and pharma companies across the full drug development value chain — from drug target validation to clinical trial design and label expansion. Our initial focus is DNA repair deficient cancers — including novel targeted therapies for PARPi resistant BRCA-mutated cancers — and we are now scaling across oncology indications and rare genetic diseases, where variant-level functional data is equally transformative. Our platform generates clean, endogenous gene variant data with zero off-target noise — ideal for training and validating AI-driven clinical decision tools. We combine geneSlice cell models, partner clinical data, and AI-powered analysis to create the data infrastructure next-generation precision medicine requires. We are an ambitious team based in Amsterdam and remote locations. If you are driven by mechanistic insight at the intersection of functional genomics, oncology, and rare disease — and want your work to reach patients — we would love to hear from you.