The Prototype JavaScript Framework is a JavaScript framework as part of the foundation for Ajax support in Ruby on Rails. It is implemented as a single file of JavaScript code, usually named prototype.js.
script.aculo.us is a JavaScript library built on the Prototype JavaScript Framework, providing dynamic visual effects and user interface elements via the Document Object Model (DOM). It is most notably included with Ruby on Rails and Seaside, but also provided separately to work with other web frameworks and scripting languages.
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