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The American Medical Association (AMA) is the largest and most influential organization representing the voices of hundreds of thousands of physicians, residents and medical students across the United States. Founded in 1847, the AMA works to advance the interests of physicians and patients by advocating for policies that improve access to quality care, strengthen the patient-physician relationship, promote physician autonomy and wellbeing, advance science and technology, and uphold the high medical ethics of the profession. The AMA’s mission is to promote the art and science of medicine and the betterment of public health. For more information, visit ama-assn.org. For commenting policies, see our Code of Conduct: http://bit.ly/1aEMHr2

Springer Nature publishes journals, databases and online products and services across the life, physical and applied sciences and, most recently, clinical medicine. Content encompasses daily news from award-winning journalists, expert opinion and practical methodology, and more high impact research and reviews than any science publisher. Over 70 journals are published, some in association with prestigious academic societies. Nature Portfolio provides news content through Nature News. Scientific career information and free job postings are offered on Naturejobs. Nature was first published in 1869. Springer Nature has its principal offices in London, New York and Tokyo with offices in offices in Basingstoke, Boston, Buenos Aires, Delhi, Hong Kong, Madrid, Melbourne, Munich, Paris, San Francisco, Seoul and Washington DC.