geneXplain Information

At geneXplain, we help researchers uncover the molecular mechanisms driving gene regulation, disease, and drug response through expertly curated biological knowledge and advanced bioinformatics. We are the developers of TRANSFAC, a leading manually curated resource for transcription factor binding sites, DNA-binding proteins and gene regulation. Built over 38 years of experimental evidence, it helps researchers identify transcriptional regulators, reconstruct gene regulatory networks, and generate meaningful biological hypotheses. Our integrated solutions support the complete discovery workflow from gene lists to regulatory mechanisms, biomarkers, therapeutic targets, and drug discovery. 𝐓𝐑𝐀𝐍𝐒𝐅𝐀𝐂: Identify the transcription factors driving gene expression using the world's leading manually curated database of transcription factors, binding sites, and DNA-binding models. 𝐌𝐀𝐓𝐂𝐇™ 𝐒𝐮𝐢𝐭𝐞: Automated transcription factor binding site analysis that transforms gene lists into regulatory insights in minutes. 𝐓𝐑𝐀𝐍𝐒𝐏𝐀𝐓𝐇: Reconstruct signaling pathways, trace upstream regulatory cascades, and identify master regulators controlling cellular responses. 𝐇𝐮𝐦𝐚𝐧𝐏𝐒𝐃: Connect genes, pathways, biomarkers, diseases, and therapeutic targets to interpret molecular findings in a clinical and disease context. 𝐆𝐞𝐧𝐨𝐦𝐞 𝐄𝐧𝐡𝐚𝐧𝐜𝐞𝐫: An automated multi-omics pipeline that uses TRANSFAC, TRANSPATH, and HumanPSD™ to identify key TFs, master regulators, biomarkers, and therapeutic targets. 𝐠𝐞𝐧𝐞𝐗𝐩𝐥𝐚𝐢𝐧 𝐏𝐥𝐚𝐭𝐟𝐨𝐫𝐦: A cloud-based bioinformatics environment integrated with our curated databases, offering 200+ methods for omics and multi-omics analysis. geneXplain's solutions are trusted by 200,000+ users and have powered 30,000+ scientific publications across academic research, biotech, pharma R&D, and AI-driven biology providing the curated biological knowledge and analytical tools to turn complex omics data into actionable insights.