Dim Information

DIM is a standardized, bioavailable form of diindolylmethane, ... As a patented formula, DIM promotes women's metabolism and cellular health. DIM-plus contains diindolylmethane, a phytonutrient found in cruciferous ... DIM has unique hormonal benefits. For example, it supports the activity of ... Diindolylmethane (DIM) is a stable indole found in cruciferous vegetables which promotes a beneficial estrogen metabolism in both women and men. Pure Diindolylmethane is insoluble and poorly absorbed by the human body. Michael A. Zeligs, M.D. was awarded a U.S. Patent for absorption-enhanced microencapsulated Diindolylmethane, making it the only formulation shown in humans to improve estrogen metabolism. Much of the research summarized here used Dr. Zeligs' microencapsulated, absorption-enhanced formulation of DIM. *All published clinical studies have ONLY used the patented microencapsulated formulation of DIM. The following definition of diindolylmethane was taken from the National Cancer Institute: diindolylmethane A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown.