Diagnostics Development Information

Three recent publications ( HNL JIM 2015 , HNL CVI 2015, and CVI 2017 ) showed the superiority of HNL as a diagnostic and discriminatory means in infectious disease. Reviews on HNL were published in 2018 and 2019 ( HNL UJMS , HNL JALM ). Recent important publications on HNL are the multimarker approach-publication in which the diagnostic performance was strengthened by combining with other biomarkers such as IP-10 ( HNL JIM 2019 ) and most recentlt the publication showing the utility of plasma measurement of HNL in combination with TK1 (Thymidine kinase 1) in the distinction between bacterial and mycoplasma ( HNL and Mycoplasma 2020 ). Diagnostics Development is building strong alliances with major partners on the global diagnostics market. HNL is currently in focus, but our ambitions are to build further on our long-standing research and experience on the use of assays of specific secretory proteins of neutrophils and eosinophils for the purpose of monitoring the activity and turnover of these important inflammatory cells in disease. These proteins are the eosinophil proteins ECP, EPO, EDN and the neutrophil proteins MPO and PLBII-P In our recent publication on fMLP-activated whole blood we showed that it was possible to achieve an even greater diagnostic distinction between acute infections caused by bacteria or virus by adding some other biomarkers to the algorithm. The distinction approached an unlikely 100% sensitivity and specificity by adding either serum concentrations of IP-10 and/or TRAIL to the diagnostic algorithm. In the same report the algorithm that had replaced HNL by CRP was good but obviously inferior to the inclusion of HNL Take a look at the figure at the bottom showing this by comparing areas under the ROC curve. An important notice about the assay of eosinophil and neutrophil granule proteins in serum. Avoid blood collection tubes containing clot activators in the form of silica microcrystalls!!!The measurements of secretory granule proteins such as HNL, ECP and others in serum require ...