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Our current portfolio includes novel clinical-stage assets, namely praliciguat and olinciguat, as well as multiple research stage molecules. Praliciguat is a systemic sGC stimulator that is exclusively licensed to Akebia and is being advanced in rare kidney disease. Olinciguat is a vascular sGC stimulator that Cyclerion intends to develop itself or out-license for cardiovascular diseases. Concurrently, we are also evaluating other activities aimed at enhancing shareholder value, which potentially include collaborations, licenses, mergers, acquisitions and/or other targeted investments. In addition, Cyclerion holds 10 percent equity ownership in Tisento Therapeutics as part of an asset purchase agreement in which Tisento acquired the brain-penetrant sGC stimulators zagociguat and CY3018.

Cyclerion Questions

The Cyclerion annual revenue was $26 million in 2026.

Regina Graul is the CEO of Cyclerion.

5 people are employed at Cyclerion.

Cyclerion is based in Cambridge, Massachusetts.

The NAICS codes for Cyclerion are [54171, 541, 3254, 325, 54, 5417, 541712, 32].

The SIC codes for Cyclerion are [283, 28, 873, 87].

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