ConnectomX Information

ConnectomX is redefining access to high-resolution volume electron microscopy through compact, innovative solutions. Founded in 2018, ConnectomX builds a complete ecosystem for serial block-face SEM (SBF-SEM). Our katana microtome — a universal in-chamber ultramicrotome — transforms virtually any scanning electron microscope into a powerful 3D imaging system in minutes, with nanometre-precise sectioning and plug-and-play installation. Paired with the Kensho BSED, our high-sensitivity backscattered electron detector delivers an industry-leading 56:1 signal-to-noise ratio at ultra-short working distances, while its fully motorised insertion ensures seamless, repeatable positioning. For non-conductive samples, our Precision Charge Neutralisation system eliminates charging artifacts using a proprietary supersonic gas jet — all while preserving high-vacuum imaging conditions. Tying it all together, Samurai 3 — our smart acquisition software — brings intelligent automation to SBF-SEM with dynamic tile selection, autofocus, debris detection, and fault-tolerant persistence that ensures zero data loss. With successful deployments across global research institutions and official integrations with TESCAN and JEOL platforms, we empower scientists to uncover biological and materials structures with unprecedented efficiency. We believe the future of microscopy is modular, intelligent, and user-driven. At ConnectomX, we are building that future — slice by slice.