Collaborative Medicinal Development LLC Competitors

Applied Therapeutics is a clinical-stage biopharmaceutical company developing a pipeline of novel drug candidates against validated molecular targets in indications of high unmet medical need. Applied Therapeutics' portfolio includes three Phase 3 programs for diseases with high unmet medical need and no approved treatment options. The Company's lead drug candidate, AT-007, is a novel central nervous system penetrant Aldose Reductase Inhibitor (ARI) for the treatment of CNS rare metabolic diseases, including Galactosemia and SORD Deficiency. The Company is also developing AT-001, a novel potent ARI, for the treatment of Diabetic Cardiomyopathy, or DbCM, a fatal fibrosis of the heart.

BrainStorm Cell Therapeutics Inc. (NASDAQ) develops autologous stem cell therapies for neurodegenerative disorders such as ALS, MS, and Parkinson’s disease. These diseases have limited treatment options and represent unmet medical needs. NurOwn® is BrainStorm’s proprietary process for differentiating autologous mesenchymal stem cells (MSC) into neurotrophic factor (NTF)-secreting cells, transplanted at or near the affected tissue site. Our technology converts MSCs into a living drug delivery system for NTFs. We have proof-of-concept in various animal models of neurodegenerative diseases, including Parkinson's, Huntington's, ALS, MS, and peripheral nerve injury. We have completed two single-arm clinical trials in ALS patients in Israel, demonstrating good safety and tolerability profiles and strong efficacy signals. We also finalized a Phase 3 randomized, double-blind, placebo-controlled clinical trial at multiple US sites, supported by a $16 million USD grant from the California Institute for Regenerative Medicine (CIRM) and another grant from the ALS Association. Currently, we are planning a Phase 3b clinical trial of NurOwn® in ALS under a Special Protocol Assessment (SPA) with the U.S. Food and Drug Administration (FDA). For more information, visit www.brainstorm-cell.com

Neuropore Therapies, Inc. is a San Diego, California based biopharmaceutical company focused on the discovery and development of novel small molecule therapeutics for the treatment Parkinson’s disease and other neurodegenerative disorders. The approaches applied by Neuropore Therapies target the core pathological processes underlying these disorders including the intracellular accumulation of neurotoxic misfolded proteins and neuroinflammation. The first clinical candidate to emerge from our discovery efforts is NPT200-11. This is an orally bioavailable small molecule that uniquely targets the earliest steps in the processes leading to the formation of alpha-synuclein (ASYN) toxic oligomeric protein aggregates involved in Parkinson’s disease (PD) and other related disorders. Concomitant with our successful execution of a Phase 1 clinical trial, this candidate was out-licensed to UCB Pharma for a total potential value of $480 million plus up to double digit royalties on net sales. Beyond the continuing development of NPT200-11, Neuropore Therapies is advancing a number of additional preclinical stage compounds, with complementary mechanisms of action (i.e. enhancing the clearance of proteins that have already formed toxic aggregates and/or mitigating their toxic neuroinflammatory actions). For more information visit: www.neuropore.com