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ChemSpider is a free chemical structure database providing fast access to over 58 million structures, properties, and associated information. By integrating and linking compounds from ~500 data sources, ChemSpider enables researchers to discover the most comprehensive view of freely available chemical data from a single online search. It is owned by the Royal Society of Chemistry. ChemSpider builds on the collected sources by adding additional properties, related information, and links back to original data sources. ChemSpider offers text and structure searching to find compounds of interest and provides unique services to improve this data by curation and annotation, and to integrate it with users’ applications. ChemSpider SyntheticPages (CS|SP) extends this model to cover reactions, providing quick publication, peer review and semantic enhancement of repeatable reactions. ChemSpider won three international awards in 2010: the ALPSP Prize for Publishing Innovation, the Bio-IT World "Best Practices" award for Community Contribution, and the iExpo/KM forum "Most Innovative Software" award.

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The ChemSpider annual revenue was $13 million in 2024.

ChemSpider is based in Wake Forest, North Carolina.

The NAICS codes for ChemSpider are [517110, 5171, 51, 51711, 517].

The SIC codes for ChemSpider are [73, 737, 7375].

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