BlazeMetrics PAT In-Process Microscopy, Spectroscopy, & Analytics Information

Complementary Enabling Best-in-Class PATs in a Single Probe: 14-Bit HDR Microscopy: High contrast, high resolution, & high dynamic range in-process microscopy enables a next generation understanding of single & multiple dispersed phase particle systems at the highest solids, smallest particle sizes, and widest range of particle composition types. Image Analysis Derived CLD (Chord Length Distribution): Blaze Image Derived Chord Length Distributions (ID-CLD) provide data and trends familiar to thousands of process development experts but with substantially improved linearity, precision, accuracy and repeatability over changing dispersed phase properties (solids concentration/size/shape/surface/translucent-opacity). These improvements lead to better and faster process understanding and hence shorter development times and often better and more robust processes. 14-Bit HDR Turbidity: Extends the measurable range between the minimum detectable value of back-scattered light (no to low dispersed phase i.e. earlier cloud point detection vs traditional tools) to the largest amount of back-scattered light (highest dispersed phase concentration with the smallest particle sizes -- hence the most scattering surface area -- i.e. detecting attrition or size reduction at the highest solids loading and smallest sizes). Particle Focused Raman: Improves signal from suspended solids. Depending on the conditions, the Blaze can substantially increase the solids signal captured dynamically in process. This enables users to better identify small volumes and/or track small changes in polymorphs, solvates, hydrates, & particulate impurities; as well as better differentiate particle types in multiple component systems. Blaze Raman pairs with most spectrometers. OPC Bi-directional Communication: Blaze uses OPC to transfer statistics between the Blaze and Process Control Software.